电分析化学国家重点实验室

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李壮 研究员
文章来源:发布时间:2011-12-16

  李壮 研究员
 
博士生导师
 
 
房间号:无机分析楼413室
电话:0431-85262057
传真:0431-85262057
E-mail:zli@ciac.jl.cn
 

教育和工作经历

1998年-至今,长春应用化学研究所电分析国家重点实验室副主任,研究员,博士生导师。中国科学院研究生院教授。
1995-1998年,长春应用化学研究所电分析化学开放实验室,副研究员
1991-1993年,吉林大学光化学研究室,博士后

1983-1984年,陕西省榆林地区教研室,教学研究员 
1991年,中国科学院长春应用化学研究所,分析化学专业, 理学博士 
1987年,中国科学院长春应用化学研究所,高分子化学专业,理学硕士

1983年,延安大学,理学学士 

 

主要荣誉

获中国科学院自然科学三等奖一次。
2003年吉林省科学进步一等奖(扫描探针显微技术在电化学和生命科学中的研究基础,排名第三)。
2004年吉林省科学技术进步一等奖(功能化电极界面的研究——从化学修饰到自组装,排名第五)。

 

研究资助

(1) 纳米材料与纳米技术在水污染检测与治理中的应用基础研究,主持,2010-01--2014-12
(2) 脑中化学信息物质的时间分辨分析,主持,2008-01--2010-12
(3) 可控纳米线的制备及表面增强拉曼散射研究,主持 2008-01--2010-12

 

研究方向

扫描探针显微学及电化学,DNA/蛋白质结构及相互作用可视化研究,纳米器件及痕量分析

 

代表性研究成果介绍

1. 提出了利用原子力显微镜制作基因组DNA高分辨物理图的概念,改进和发展了DNA、单链DNA及DNA/限制性内切酶络合物样品制备方法;获得了限制性内切酶EcoRI在DNA质粒pBR322上酶切点和星号活力高分辨物理图;为发展快速、精确、简便的用于解决大规模DNA测序中排序与组装困难的高分辨物理图提供了可能。组织研制成功了高效节水渗灌溉,为解决农业灌溉缺水及废旧橡胶、废旧高分子材料对环境污染问题做出了贡献。
2. 提出利用纳米点样笔技术和纳米粒子搬动技术,制作直径、长度、形状、种类可控纳米导线及纳米阵列电极方法,为直接实现纳米器件的连接和纳米电化学器件的制备提供条件

3. 提出利用原子力显微镜进行微区定位的几种新方法,研究了DNA分子与各种金属盐离子之间的相互作用,在此基础上构筑了各种图案化的DNA结构,并成功用作粒子组装的模板;

4. 探索了具有催化及拉曼活性的金银铂等纳米结构的合成方法及组装性质;研究了胶原蛋白,DNA等生物分子的自组装特性,以其组装膜为模板,构筑了具有高活性的拉曼增强基底,应用于DNA及其碱基的SERS检测;

5. 提出了将样品浓缩到微米、纳米斑点,为实现超高灵敏拉曼、表面增强拉曼、荧光及发光等检测奠定了基础。

 

主要代表性论文

(1) Assembly of Ni(OH)2 nanoplates on graphene: a two dimensional nanocomposite for enzymefree glucose sensing,J. Mater. Chem.,2011,通讯作者
(2) Silver Nanoparticles Coated Zinc Oxide Nanorods Array as Superhydrophobic Substrate for the Amplified SERS Effect,J. Phys. Chem. C,2011,通讯作者
(3) DNA adsorption and desorption on mica surface studied by atomic force microscopy,Appl. Surf. Sci.,2011,通讯作者
(4) Formation of Gold Nanoparticle Decorated Lysozyme Microtubes,Biomacromolecules,2011,通讯作者
(5) Au nanocages for highly sensitive and selective detection of H2O2,J. Electroanal. Chem.,2011,通讯作者
(6) Carbon nanotube decorated with silver nanoparticles via noncovalent interaction for a novel nonenzymatic sensor towards hydrogen peroxide reduction,J. Electroanal. Chem.,2011,通讯作者
(7) Interaction between DNA and Microcystin-LR Studied by Spectra Analysis and Atomic Force Microscopy,Biomacromolecules,2011,通讯作者
(8) Facile Synthesis of Urchin-Like Gold Submicrostructures for Nonenzymatic Glucose Sensing,Talanta,2010,通讯作者
(9) Seed-Mediated Synthesis of Au Nanocages and Their Electrocatalytic Activity towards Glucose Oxidation,Chem-Eur. J.,2010,通讯作者
(10) Facile fabrication of single crystal gold nanoplates with micrometer lateral size,Colloid Surf. A-Physicochem. Eng. Asp.,2010,通讯作者 
(11) Novel nonenzymatic hydrogen peroxide sensor based on iron oxide-silver hybrid submicrospheres,Talanta ,2010,通讯作者
(12) Carbon nanotube/raspberry hollow Pd nanosphere hybrids for methanol, ethanol, and formic acid electro-oxidation in alkaline media,J. Colloid. Interf. Sci. ,2010,通讯作者
(13) Type I collagen-mediated synthesis of noble metallic nanoparticles networks and the applications in ,Talanta,2009,通讯作者
(14) Influence of Polyelectrolyte on DNA-RecA Nucleoprotein Filaments: Poly-L-Lysine Used as a Model,ChemPhysChem,2009,通讯作者
(15) Surface Relevant Regulable DNA Toroids Induced by Dopamine,J. Phys. Chem. B,2009,通讯作者
(16) Electrodeposition of Platinum Nanoclusters on Type I Collagen Modified Electrode and its Electrocata,Appl. Surf. Sci.,2009,通讯作者
(17) Novel Hybrid Electrocatalyst with Enhanced Performance in Alkaline Media: Hollow Au/Pd Core/Shell Nanostructures with a Raspberry Surface,J. Phys. Chem. C,2009,通讯作者
(18) Type I collagen-templated assembly of silvernanoparticles and their application in surface-enhanced ,Nanotechnology,2008,通讯作者
(19) Controllable synthesis of gold nanowires,Mater. Lett.,2008,通讯作者
(20) Photochemical synthesis and self-assembly of gold nanoparticles,Colloids and Surfaces A: Physicochem. Eng. Aspects,2008,通讯作者
(21) Aggregation-based growth of silver nanowires at room temperature,Appl. Surf. Sci,2008,通讯作者
(22) Self-assembly of λ-DNA networks/Ag nanoparticles: Hybrid architecture, and active-SERS substrate,J. Colloid Interface Sci.,2008,通讯作者
(23) DNA-Templated Gold Nanoparticles Formation,J. Nanosci. Nanotechno.,2008,通讯作者
(24) Ethanol-Induced Formation of Silver Nanoparticle Aggregates for Highly Active SERS Substrates and Ap,J. Phys. Chem. C,2008,通讯作者
(25) Atomic Force Microscopic Study of Low Temperature Induced Disassembly of RecA-dsDNA Filaments,J. Phys. Chem. B,2008,通讯作者
(26) Fabrication, characterization, and application in surface-enhanced Raman spectrum of assembled type-,J. Chem. Phys. ,2008,通讯作者
(27) Electrostatic assembly of protein lysozyme on DNA visualized by atomic force microscopy,Appl. Surf. Sci.,2007,通讯作者
(28) Room temperature ionic liquid doped DNA network immobilized horseradish peroxidase biosensor for amp,Anal. Bioanal. Chem.,2007,通讯作者
(29) Controlled organization of silver nanoparticles into network assemblies by tuning pH values,Chem. Lett.,2007,通讯作者
(30) Large-scale, uniform DNA network on 11-mercaptoundecanoic acid modified gold (111) surface: Atomic f,Microsc. Res. Tech.,2007,通讯作者
(31) Self-assembled gold nanoparticle chains in presence of silver ions,Chem. Lett.,2007,通讯作者
(32) Effects of bridge ions, DNA species, and developing temperature on flat-lying DNA monolayers, J. Phys. Chem. B,2007,通讯作者
(33) Synthesis, characterization, and self-assembly of protein lysozyme monolayer-stabilized gold nanopar,Langmuir,2007,通讯作者
(34) Type I Collagen-Mediated Synthesis and Assembly of UV-Photoreduced Gold Nanoparticles and Their Appl,J. Phys. Chem. C,2007,通讯作者
(35) Electrostatic assembly of Cu2O nanoparticles on DNA templates,Appl. Surf. Sci.,2006,通讯作者
(36) Fabrication of silver nanoparticles ring template by plasmid DNA,Appl. Surf. Sci.,2006,通讯作者
(37) Manipulation, dissection, and lithography using modified tapping mode atomic force microscope,Microsc. Res. Tech.,2006,通讯作者
(38) Diluting thiol-derivatized oligonucleotide monolayers on Au(111) by mercaptohexanol replacement reac,Appl. Surf. Sci.,2006,通讯作者
(39) Solution-phase synthesis of Au@ZnO core-shell composites,Mater. Lett.,2006,通讯作者
(40) Hydrogen peroxide sensor based on horseradish peroxidase immobilized on a silver nanoparticles/cyste,Anal. Bioanal. Chem.,2006,通讯作者
(41) A novel hydrogen peroxide sensor based on horseradish peroxidase immobilized in DNA films on a gold ,Sens. Actuators, B,2006,通讯作者
(42) A novel strategy to construct a flat-lying DNA monolayer on a mica surface,J. Phys. Chem. B,2006,通讯作者
(43) Self-assembly of cinnamic acid-capped gold nanoparticles,Nanotechnology,2006,通讯作者
(44) Fabrication of linear aniline-DNA complex nanowires and DNA-templated polyaniline nanowires,Chem. J. Chin. Univ.-Chin.,2006,通讯作者
(45) Observation of the mica surface by atomic force microscopy,Micron,2005,通讯作者
(46) Immobilization and condensation of DNA with 3-aminopropyltriethoxysilane studied by atomic force mic,Journal of Microscopy-Oxford,2005,通讯作者
(47) Nanoscale structures of circle-MgCl2 constructed by plasmid DNA templates,Superlattices Microstruct.,2005,通讯作者
(48) A simple method for the preparation of ultrahigh sensitivity surface enhanced Raman scattering (SERS,Appl. Surf. Sci.,2005,通讯作者
(49) Electrostatic assembly of CTAB-capped silver nanoparticles along predefined λ-DNA template,Appl. Surf. Sci.,2005,通讯作者
(50) DNA-network-templated self-assembly of silver nanoparticles and their application in surface-enhance,J. Phys. Chem. B,2005,通讯作者
(51) Covalent assembly of shortened multiwall carbon nanotubes on polyelectrolyte films and relevant elec,J. Colloid. Interface. Sci.,2005,通讯作者
(52) Immobilization of DNA on 11-mercaptoundecanoic acid-modified gold(111) surface for atomic force micr,Microsc. Res. Tech.,2005,通讯作者
(53) Imaging DNA molecules on mica surface by atomic force microscopy in air and in liquid,Microsc. Res. Tech.,2005,通讯作者
(54) Mechanically engraved mica surface using the atomic force microscope tip facilitates return to a spe,Microsc. Res. Tech.,2005,通讯作者
(55) Synthesis of nanowires, nanorods and nanoparticles of ZnO through modulating the ratio of water to m,Mater. Chem. Phys.,2005,通讯作者
(56) One-step synthesis of silver nanoparticles, nanorods, and nanowires on the surface of DNA network,J. Phys. Chem. B,2005,通讯作者
(57) Direct patterning of rhodamine 6G molecules on mica by dip-pen nanolithography,Appl. Surf. Sci.,2004,通讯作者
(58) DNA network structures on various solid substrates investigated by atomic force microscopy,Anal. Sci.,2004,通讯作者
(59) Atomic force microscope investigation of large-circle DNA molecules,Anal. Biochem. ,2004,通讯作者
(60) The influence of tip performance on scanning probe lithography,Appl. Surf. Sci.,2004,通讯作者

发表著作

(1) ,Interfacial Protein Science: Methods and Applications in Biotechnology and Materials Science. PART II: Applications. Chapter: The preparation of nanomaterials based on peptides and proteins and their applications.,John Wiley and Sons, Inc.,2011-10,第2作者
(2) ,Mica: Properties, Synthesis and Applications. Chapter: Mica, a main substrate of Atomic Force Microscope for biological and nanotechnological research.,Nova Science Publishers, Inc.,2011-08,第2作者
(3) ,Biomedical Engineering - Frontiers and Challenges. Chapter: Formation of Gold Nanoparticle Decorated Lysozyme Microtubes,InTech - Open Access Publisher,2011-08,第1作者
(4) 《生命分析化学》第十九章 扫描探针显微镜,科学出版社,2006-07
(5) 《现代高分子物理学》第十五章 原子力显微镜,科学出版社,2003-04

研究组人员概况

孙玉静 (博士)助理研究员 

李红云 高级实验师

胡婧婷(硕士) 

张悦  博士研究生  

石岩  博士研究生

温志伟 硕士研究生  

戴海潮 硕士研究生  

倪朋娟 硕士研究生